Comorbid Description and Neutrophil Lymphocyte Ratio in COVID-19 Patients (Suspect and Confirmed Patients)

Authors

  • Subrata Tri Widada Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Yogyakarta, Yogyakarta, Indonesia
  • Marta Atik Martsiningsih Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Yogyakarta, Yogyakarta, Indonesia
  • Bambang Supriyanta Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Yogyakarta, Yogyakarta, Indonesia
  • Sistiyono Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Yogyakarta, Yogyakarta, Indonesia
  • Suyana Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Yogyakarta, Yogyakarta, Indonesia
  • Siti Nuryani Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Yogyakarta, Yogyakarta, Indonesia
  • Budi Setiawan Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Yogyakarta, Yogyakarta, Indonesia and Pusat Unggulan IPTEK Inovasi Teknologi Kesehatan Masyarakat, Politeknik Kesehatan Kementerian Kesehatan Yogyakarta, Yogyakarta, Indonesia
  • Dwi Sulistyowati General Hospital of Cilacap Region, Cilacap, Central Java, Indonesia
  • Muji Rahayu Department of Medical Laboratory Technology, Poltekkes Kemenkes Yogyakarta, Indonesia

DOI:

https://doi.org/10.31965/infokes.Vol20.Iss2.1002

Keywords:

NLR, RT-PCR, COVID-19

Abstract

Neutrophil Lymphocyte Ratio (NLR) is a laboratory available as a marker used for the evaluation of systemic inflammation, NLR is a significant predictor and is a critical prognosis for COVID-19 infection and can serve as a useful factor to reflect the intensity of the imbalance of inflammation and immune response in COVID-19 patients. This study aims to determine the difference in NLR values in negative and confirmed COVID-19 patients and description for comorbid for both. This study is an analytic observational study with a cross-sectional design. The study sample was 423 suspected COVID-19 patients at hospitals in Cilacap district for the period in March – October 2020. The data obtained were analyzed descriptively and using the fisher-exact test. In these results from suspected patients with negative COVID-19, lung illness were present 31.8%, viral infections 22.9%, other respiratory disorders 6.1%, diabetes mellitus 4.7%, and anemia 4.7%. Whereas suspected patients with confirmed COVID-19 were, without comorbid diseases (40.2%), lung disease (12.4%), diabetes mellitus (7.7%), hypertension (6.2%), and other respiratory illnesses (5.2%). The mean of NLR in confirmed patients is 3.57 but not any difference between negative and confirmed patients COVID-19, but there’s any a relationship between NLR and ARDS conditions.

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References

Ballesteros, I., Rubio-Ponce, A., Genua, M., Lusito, E., Kwok, I., Fernández-Calvo, G., Khoyratty, T. E., van Grinsven, E., González-Hernández, S., Nicolás-Ávila, J. Á., Vicanolo, T., Maccataio, A., Benguría, A., Li, J. L., Adrover, J. M., Aroca-Crevillen, A., Quintana, J. A., Martín-Salamanca, S., Mayo, F., … Hidalgo, A. (2020). Co-option of Neutrophil Fates by Tissue Environments. Cell, 183(5), 1282-1297.e18. https://doi.org/10.1016/j.cell.2020.10.003

Biscayart, C., Angeleri, P., Lloveras, S., Chaves, T. do S. S., Schlagenhauf, P., & Rodríguez-Morales, A. J. (2020). The next big threat to global health? 2019 novel coronavirus (2019-nCoV): What advice can we give to travellers? – Interim recommendations January 2020, from the Latin-American society for Travel Medicine (SLAMVI). Travel Medicine and Infectious Disease, 33, 101567. https://doi.org/10.1016/j.tmaid.2020.101567

Cahyadi, A., & Steffanus, M. (2018). Perbedaan Nilai Rasio Neutrofil Terhadap Limfosit Pada Pasien Tuberkulosis Dewasa Sebelum dan Setelah Terapi Fase Intensif di RS Atma Jaya. Journal of The Indonesian Medical Association, 68(10), 415-419. Retrieved from https://mki-ojs.idionline.org/jurnal/article/view/211

Chairani, I. (2020). Dampak Pandemi COVID-19 Dalam Perspektif Gender di Indonesia. Jurnal Kependudukan Indonesia, Edisi Khusus Demografi dan COVID-19, 39-42. https://doi.org/10.14203/jki.v0i0.571

Frater, J. L., Zini, G., d’Onofrio, G., & Rogers, H. J. (2020). COVID‐19 and the clinical hematology laboratory. International Journal of Laboratory Hematology, 42(S1), 11–18. https://doi.org/10.1111/ijlh.13229

Guan, W., Ni, Z., Hu, Y., Liang, W., Ou, C., He, J., Liu, L., Shan, H., Lei, C., Hui, D. S. C., Du, B., Li, L., Zeng, G., Yuen, K.-Y., Chen, R., Tang, C., Wang, T., Chen, P., Xiang, J., … Zhong, N. (2020). Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal of Medicine, 382(18), 1708–1720. https://doi.org/10.1056/NEJMoa2002032

Guo, Y.-R., Cao, Q.-D., Hong, Z.-S., Tan, Y.-Y., Chen, S.-D., Jin, H.-J., Tan, K.-S., Wang, D.-Y., & Yan, Y. (2020). The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status. Military Medical Research, 7, 11. https://doi.org/10.1186/s40779-020-00240-0

Henry, B. M., de Oliveira, M. H. S., Benoit, S., Plebani, M., & Lippi, G. (2020). Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): A meta-analysis. Clinical Chemistry and Laboratory Medicine (CCLM), 58(7), 1021–1028. https://doi.org/10.1515/cclm-2020-0369

Hidayati, D. (2020). Profil Penduduk Terkonfirmasi Positif COVID-19 dan Meninggal: Kasus Indonesia dan DKI Jakarta. Jurnal Kependudukan Indonesia, Edisi Khusus Demografi dan COVID-19, 93-100. https://doi.org/10.14203/jki.v0i0.541

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., … Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 395(10223), 497–506. https://doi.org/10.1016/S0140-6736(20)30183-5

Jaillon, S., Ponzetta, A., Di Mitri, D., Santoni, A., Bonecchi, R., & Mantovani, A. (2020). Neutrophil diversity and plasticity in tumour progression and therapy. Nature Reviews Cancer, 20(9), 485–503. https://doi.org/10.1038/s41568-020-0281-y

Liew, P. X., & Kubes, P. (2019). The Neutrophil’s Role During Health and Disease. Physiological Reviews, 99(2), 1223–1248. https://doi.org/10.1152/physrev.00012.2018

Liu, J., Li, S., Liu, J., Liang, B., Wang, X., Li, W., Wang, H., Tong, Q., Yi, J., Zhao, L., Xiong, L., Guo, C., Tian, J., Luo, J., Yao, J., Pang, R., Shen, H., Peng, C., Liu, T., … Zheng, X. (2020). Longitudinal Characteristics of Lymphocyte Responses and Cytokine Profiles in the Peripheral Blood of SARS-CoV-2 Infected Patients. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3539682

Liu, J., Liu, Y., Xiang, P., Pu, L., Xiong, H., Li, C., Zhang, M., Tan, J., Xu, Y., Song, R., Song, M., Wang, L., Zhang, W., Han, B., Yang, L., Wang, X., Zhou, G., Zhang, T., Li, B., … Wang, X. (2020). Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage. Journal of Translational Medicine, 18, 206. https://doi.org/10.1186/s12967-020-02374-0

Louis-Jean, J., & Aime, M. (2020). On the novel coronavirus (COVID-19): A global pandemic. Jurnal Teknologi Laboratorium, 9(1), 103–114. https://doi.org/10.29238/teknolabjournal.v9i1.230

McMichael, T. M., Currie, D. W., Clark, S., Pogosjans, S., Kay, M., Schwartz, N. G., Lewis, J., Baer, A., Kawakami, V., Lukoff, M. D., Ferro, J., Brostrom-Smith, C., Rea, T. D., Sayre, M. R., Riedo, F. X., Russell, D., Hiatt, B., Montgomery, P., Rao, A. K., … Duchin, J. S. (2020). Epidemiology of Covid-19 in a Long-Term Care Facility in King County, Washington. New England Journal of Medicine, 382(21), 2005–2011. https://doi.org/10.1056/NEJMoa2005412

Osman, O., Bolatli, G., & Tas, F. (2020). Investigation of revers-transcriptase polymerase chain reaction values of patients with COVID-19 findings in lung computed tomography results. Jurnal Teknologi Laboratorium, 9(1), 41–48. https://doi.org/10.29238/teknolabjournal.v9i1.220

Oudit, G. Y., & Pfeffer, M. A. (2020). Plasma angiotensin-converting enzyme 2: Novel biomarker in heart failure with implications for COVID-19. European Heart Journal, 41(19), 1818–1820. https://doi.org/10.1093/eurheartj/ehaa414

Peng, J., Qi, D., Yuan, G., Deng, X., Mei, Y., Feng, L., & Wang, D. (2020). Diagnostic value of peripheral hematologic markers for coronavirus disease 2019 (COVID‐19): A multicenter, cross‐sectional study. Journal of Clinical Laboratory Analysis, 34(10). https://doi.org/10.1002/jcla.23475

Ren, L.-L., Wang, Y.-M., Wu, Z.-Q., Xiang, Z.-C., Guo, L., Xu, T., Jiang, Y.-Z., Xiong, Y., Li, Y.-J., Li, X.-W., Li, H., Fan, G.-H., Gu, X.-Y., Xiao, Y., Gao, H., Xu, J.-Y., Yang, F., Wang, X.-M., Wu, C., … Wang, J.-W. (2020). Identification of a novel coronavirus causing severe pneumonia in human: A descriptive study. Chinese Medical Journal, 133(9), 1015–1024. https://doi.org/10.1097/CM9.0000000000000722

Retnoningrum, D., Widyastiti, N. S., & Jaludamascena, A. (2018). Hubungan Antara Neutrophil/Lymphocyte Ratio (NLR) Dan High Density Lipoprotein (HDL) Pada Sindrom Koroner Akut. Media Medika Muda, 2(2), 131-136. Retrieved from https://ejournal2.undip.ac.id/index.php/mmm/article/view/2638/0

Reusch, N., De Domenico, E., Bonaguro, L., Schulte-Schrepping, J., Baßler, K., Schultze, J. L., & Aschenbrenner, A. C. (2021). Neutrophils in COVID-19. Frontiers in Immunology, 12, 652470. https://doi.org/10.3389/fimmu.2021.652470

Rothan, H. A., & Byrareddy, S. N. (2020). The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Journal of Autoimmunity, 109, 102433. https://doi.org/10.1016/j.jaut.2020.102433

Sun, P., Qie, S., Liu, Z., Ren, J., Li, K., & Xi, J. (2020). Clinical characteristics of hospitalized patients with SARS‐CoV‐2 infection: A single arm meta‐analysis. Journal of Medical Virology, 92(6), 612–617. https://doi.org/10.1002/jmv.25735

Susilo, A., Rumende, C. M., Pitoyo, C. W., Santoso, W. D., Yulianti, M., Herikurniawan, H., Sinto, R., Singh, G., Nainggolan, L., Nelwan, E. J., Chen, L. K., Widhani, A., Wijaya, E., Wicaksana, B., Maksum, M., Annisa, F., Jasirwan, C. O. M., & Yunihastuti, E. (2020). Coronavirus Disease 2019: Tinjauan Literatur Terkini. Jurnal Penyakit Dalam Indonesia, 7(1), 45-67. https://doi.org/10.7454/jpdi.v7i1.415

Sutaryono, S., Andasari, S. D., & Kasjono, H. S. (2020). Diagnosis and epidemiology of Coronavirus (COVID-19) outbreak in Indonesia. Jurnal Teknologi Laboratorium, 9(1), 49–57. https://doi.org/10.29238/teknolabjournal.v9i1.222

Tarigan, I. L., & Arum, K. (2020). Modulation of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in receptor, innate immunity and drug antiviral candidate. Jurnal Teknologi Laboratorium, 9(1), 1–12. https://doi.org/10.29238/teknolabjournal.v9i1.214

Wibisana, K. A., Subekti, I., Antono, D., & Nugroho, P. (2019). Hubungan antara Rasio Neutrofil Limfosit dengan Kejadian Penyakit Arteri Perifer Ekstremitas Bawah pada Penyandang Diabetes Melitus Tipe 2. Jurnal Penyakit Dalam Indonesia, 5(4), 184-188. https://doi.org/10.7454/jpdi.v5i4.227

Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Song, Z.-G., Hu, Y., Tao, Z.-W., Tian, J.-H., Pei, Y.-Y., Yuan, M.-L., Zhang, Y.-L., Dai, F.-H., Liu, Y., Wang, Q.-M., Zheng, J.-J., Xu, L., Holmes, E. C., & Zhang, Y.-Z. (2020). A new coronavirus associated with human respiratory disease in China. Nature, 579(7798), 265–269. https://doi.org/10.1038/s41586-020-2008-3

Xie, X., Shi, Q., Wu, P., Zhang, X., Kambara, H., Su, J., Yu, H., Park, S.-Y., Guo, R., Ren, Q., Zhang, S., Xu, Y., Silberstein, L. E., Cheng, T., Ma, F., Li, C., & Luo, H. R. (2020). Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection. Nature Immunology, 21(9), 1119–1133. https://doi.org/10.1038/s41590-020-0736-z

Yang, A.-P., Liu, J., Tao, W., & Li, H. (2020). The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. International Immunopharmacology, 84, 106504. https://doi.org/10.1016/j.intimp.2020.106504

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Published

2022-12-31

How to Cite

Widada , S. T. ., Martsiningsih, M. A. ., Supriyanta, B., Sistiyono, Suyana, Nuryani, S., … Muji Rahayu. (2022). Comorbid Description and Neutrophil Lymphocyte Ratio in COVID-19 Patients (Suspect and Confirmed Patients). JURNAL INFO KESEHATAN, 20(2), 278–285. https://doi.org/10.31965/infokes.Vol20.Iss2.1002

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Vol. 20 No. 2 (2022): JURNAL INFO KESEHATAN

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