Characteristics and Antioxidant Activity of Sweet Potato Syrup (Ipomea Batatas (L) with Propylene Glycol Variation

Authors

  • Elisma Elisma Department of Pharmacy, Poltekkes Kemenkes Kupang
  • Maria Y. Lenggu Department of Pharmacy, Poltekkes Kemenkes Kupang
  • Marce Inggritha Takubessi Department of Pharmacy, Poltekkes Kemenkes Kupang

DOI:

https://doi.org/10.31965/infokes.Vol18.Iss1.403

Keywords:

Syrup, Propylenglycol, Antioxidant Activity, Ipomea Batatas

Abstract

Sweet Potato Leaf (Ipomea Batatas (L) contains flavonoids and polyphenols which play a role in antioxidant activity. Sweet Potato leaf extract is formulated into syrup because it is faster to be absorption compared to solid preparations and more easily to swallow. Sweet potato extract is formulated with variations in the amount of propylene glycol which is 11% (F1), 12% (F2), 13% (F3) and 0% (control). The characteristics of syrup include organoleptic tests, viscosity tests and time of flow were determine and syrup antioxidant activity testing using method 2 , 2-diphenyl-1-picrylhydrazyl (DPPH). Test results showed that all formulas have the same organoleptic properties, which are brown, sweet and slightly bitter. Weak antioxidant activity showed by IC50 and AAI values. IC50 and AAI syrup were 134 ± 19.28, 128 ± 4.04, 115 ± 13.07, and 142 ± 1.5 mg / mL and the AAI values ​​were 0.074, 0.078, 0.087 and 0.070, respectively for F1, F2, F3 and control. Statistical analysis with the Kruskal-Wallis test (p> 0.05) showed no significant IC50 differences for the three formulas and control. The increase in propylene glycol affects the viscosity and ease of pouring but not the organoleptic properties while the antioxidant activity is not significantly different from the increase in propylene glycol. It is recommended to do a hedonic test for all three formulas in further research.

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References

Ćujić, N., Šavikin, K., Janković, T., Pljevljakušić, D., Zdunić, G., & Ibrić, S. (2016). Optimization of polyphenols extraction from dried chokeberry using maceration as traditional technique. Food Chemistry, 194, 135–142. DOI: https://doi.org/10.1016/j.foodchem.2015.08.008

Damayanti, D. S. (2013). Pengaruh Pemberian Ekstrak Etanol Daun Ubi Jalar (Ipomoea Batatas L.) Terhadap Peningkatan Jumlah Trombosit Pada Tikus Jantan Galur Wistar. Skripsi. Fakultas Farmasi Universitas Jember.

Fidrianny, I., Ruslan, K., & Diani, R. (2012). Antioxidant Capacities of Various Extracts From Purple Sweet Potatoes (Ipomoea Batatas (L.) Lamk.) Tubers and Isolation of Antioxidant Compound. Jurnal Medika Planta, 2(1), 36-46.

Fu, Z., Tu, Z., Zhang, L., Wang, H., Wen, Q., & Huang, T. (2016). Antioxidant activities and polyphenols of sweet potato (Ipomoea batatas L.) leaves extracted with solvents of various polarities. Food Bioscience, 15, 11–18. DOI: https://doi.org/10.1016/j.fbio.2016.04.004

Ghasemzadeh, A., Omidvar, V., & Jaafar, H. Z. (2012). Polyphenolic content and their antioxidant activity in leaf extract of sweet potato (Ipomoea batatas). Journal of Medicinal Plants Research, 6(15), 2971-2976.

Guerra-Araiza, C., Álvarez-Mejía, A. L., Sánchez-Torres, S., Farfan-García, E., Mondragón-Lozano, R., Pinto-Almazán, R., & Salgado-Ceballos, H. (2013). Effect of natural exogenous antioxidants on aging and on neurodegenerative diseases. Free Radical Research, 47(6–7), 451–462. DOI: https://doi.org/10.3109/10715762.2013.795649

Hutabarat, N. C., & Widyawati, M. N. (2018). The Effect of Sweet Potato Leaf Decoction and Iron Tablet against Increased Hemoglobin Levels in Pregnant Women. Indonesian Journal of Health Research, 1(2), 59–65. DOI: https://doi.org/10.32805/ijhr.2018.1.2.11

Jiménez, J. A., & Martínez, F. (2006). Thermodynamic study of the solubility of acetaminophen in propylene glycol + water cosolvent mixtures. Journal of the Brazilian Chemical Society, 17(1), 125–134. DOI: https://doi.org/10.1590/S0103-50532006000100018

Khaerani, K., Barium, H., & Nonci, F. Y. (2014). Efektivitas Infusa Daun Ubi Jalar (Ipomea Batatas L) Terhadap Peningkatan Trombosit Pada Mencit (Mus musculus). Jurnal Farmasi UIN Alauddin Makassar, 2(1), 24–27.

Khusna, Y., Irawan, E. D., & Sari, L. O. R. K. (2015). Optimasi Komposisi Pelarut Gliserin dan Propilen Glikol terhadap Disolusi Tablet Meloksikam Metode Likuisolid Menggunakan Simplex Lattice Design (Optimization Composition of Glycerin and Propylene Glycol Solvent on Dissolution of Meloxycam Tablet with Li. Pustaka Kesehatan, 3(2), 257–261.

Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., & Abete, P. (2018). Oxidative stress, aging, and diseases. Clinical Interventions in Aging, 13, 757–772. DOI: https://doi.org/10.2147/CIA.S158513

Lisprayatna, L., Murti, Y. B., & Sulaiman, T. N. S. (2015). Syrup Formulation of Extract of Daun Legundi (Vitex trifolia L.). Majalah Obat Tradisional, 17(2), 34–38. DOI: https://doi.org/10.22146/tradmedj.8005

Mahato, R. I., & Narang, A. S. (2011). Pharmaceutical Dosage Forms and Drug Delivery. CRC Press.

Molyneux, P. (2004). The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin J. sci. technol, 26(2), 211-219.

Nayak, A. K., & Panigrahi, P. P. (2012). Solubility enhancement of etoricoxib by cosolvency approach. ISRN Physical Chemistry. 2012, 1-5. DOI: https://doi.org/10.5402/2012/820653

Padmawar, A., Herbals, A., Bhadoriya, U., & Mechanics, M. (2018). Glycol and glycerin: pivotal role in herbal industry as solvent/cosolvent. World J Pharm Med, 4, 153-155.

Peng, C., Wang, X., Chen, J., Jiao, R., Wang, L., Li, Y. M., Zuo, Y., Liu, Y., Lei, L., Ma, K. Y., Huang, Y., & Chen, Z.-Y. (2014). Biology of ageing and role of dietary antioxidants. BioMed Research International, 2014, 1-14. DOI: https://doi.org/10.1155/2014/831841

Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., & Bitto, A. (2017). Oxidative Stress: Harms and Benefits for Human Health. Oxidative Medicine and Cellular Longevity, 2017., 1-13. DOI: https://doi.org/10.1155/2017/8416763

Prasetyo, S. D., & M, S. (2017). Pengaruh Penambahan Propilen Glikol Dan Tween 80 Terhadap Kelarutan Fenobarbital. Majalah Farmaseutik, 6(1), Article 1. DOI: https://doi.org/10.22146/farmaseutik.v6i1.24029

Scherer, R., & Godoy, H. (2009). Antioxidant activity index (AAI) by the 2,2-diphenyl-1-picrylhydrazyl method. Food Chemistry, 112, 654–658. DOI: https://doi.org/10.1016/j.foodchem.2008.06.026

Sun, H., Mu, T., Xi, L., & Song, Z. (2014). Effects of domestic cooking methods on polyphenols and antioxidant activity of sweet potato leaves. Journal of agricultural and food chemistry, 62(36), 8982-8989. DOI: https://doi.org/10.1021/jf502328d

Zhang, C., Liu, D., Wu, L., Zhang, J., Li, X., & Wu, W. (2020). Chemical Characterization and Antioxidant Properties of Ethanolic Extract and Its Fractions from Sweet Potato (Ipomoea batatas L.) Leaves. Foods, 9(1), 15. DOI: https://doi.org/10.3390/foods9010015

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Published

2020-06-30

How to Cite

Elisma, E., Lenggu, M. Y. . ., & Takubessi , M. I. . (2020). Characteristics and Antioxidant Activity of Sweet Potato Syrup (Ipomea Batatas (L) with Propylene Glycol Variation. JURNAL INFO KESEHATAN, 18(1), 74–79. https://doi.org/10.31965/infokes.Vol18.Iss1.403

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