Pesticide Exposure and Increased Liver Enzyme Activity among Suburban Horticultural
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Horticultural farmers use chemicals such as pesticides to increase productivity and also product quality. Exposure to pesticides can cause health problems, especially in the liver. A reference for evaluating liver function is blood test results for ALT, AST, ALP, and GGT activity. The objective of this study was to characterize the transaminase enzyme activity in horticultural farmers in the southern ring road area of Jambi city, based on the risk factors associated with pesticide exposure. This study employed a cross-sectional study approach in conjunction with a descriptive method. A total of thirty-four participants were involved, and blood samples were obtained from each for analysis in a lab. A photometer was utilized in the Medical Laboratory Technology department at Health Polytechnic of Jambi to measure the activity of liver enzymes. This study found some respondents who experienced increased enzyme activity, namely ALT: 8 people (23.5%), AST: 3 people (8.8%), ALP: 1 person (2.9%), and GGT: 1 person (2.9%.). Based on the risk description observed, it was known that the intensity of pesticide exposure showed a significant increase only in ALT enzyme activity (p=0.0048), while adherence to mask-wearing increased ALT (p=0.0018) and GGT (p=0.0134). This study discovered that wearing a mask and the amount of pesticide exposure can increase enzyme activity, which may be a sign of liver impairment in the horticultural farmers under observation. It is anticipated that workers will pay greater attention to workplace safety by wearing masks and applying pesticides in the recommended dosages.
Agustina, N., & Norfai, N. (2018). Paparan Pestisida terhadap Kejadian Anemia pada Petani Hortikultura. Majalah Kedokteran Bandung, 50(4), 215–221. https://doi.org/10.15395/mkb.v50n4.1398
Amilia, E., Joy, B., & Sunardi, S. (2016). Residu Pestisida pada Tanaman Hortikultura (Studi Kasus di Desa Cihanjuang Rahayu Kecamatan Parongpong Kabupaten Bandung Barat). Agrikultura, 27(1), 23-29. https://doi.org/10.24198/agrikultura.v27i1.8473
Andarini, Y. D., & Rosanti, E. (2018). Kajian toksisitas pestisida berdasarkan masa kerja dan personal hygiene pada petani hortikultura di Desa Demangan. An-Nadaa: Jurnal Kesehatan Masyarakat (e-Journal), 5(2), 82-89. https://doi.org/10.31602/ann.v5i2.1655
Aulbach, A. D., & Amuzie, C. J. (2017). Biomarkers in Nonclinical Drug Development. In A Comprehensive Guide to Toxicology in Nonclinical Drug Development, pp. 447–471. Elsevier. https://doi.org/10.1016/B978-0-12-803620-4.00017-7
Bayili, B., Da, O., Ilboudo, S., Ouedraogo, R., Coulibaly, V. P., Bationo, J. F., ... & Ouedraogo, G. A. (2020). Study of biochemical parameters in farmers exposed to pesticides used in cotton growing around the Bala hippopotamus pond. GSC Biological and Pharmaceutical Sciences, 13(1), 111-122. https://doi.org/10.30574/gscbps.2020.13.1.0323
Bernieri, T., Rodrigues, D., Randon Barbosa, I., Perassolo, M. S., Grolli Ardenghi, P., & Basso da Silva, L. (2021). Effect of pesticide exposure on total antioxidant capacity and biochemical parameters in Brazilian soybean farmers. Drug and Chemical Toxicology, 44(2), 170–176. https://doi.org/10.1080/01480545.2019.1566353
Boedeker, W., Watts, M., Clausing, P., & Marquez, E. (2020). The global distribution of acute unintentional pesticide poisoning: Estimations based on a systematic review. BMC Public Health, 20(1), 1875. https://doi.org/10.1186/s12889-020-09939-0
BPOM. (2020). Laporan Tahunan Pusat Data dan Informasi Obat dan Makanan tahun 2019. Badan Pengawasan Obat dan Makanan.
Colombo, M., La Vecchia, C., Lotti, M., Lucena, M. I., Stove, C., Paradis, V., & Newsome, P. (2019). EASL Clinical Practice Guideline: Occupational liver diseases. Journal of Hepatology, 71(5), 1022–1037. https://doi.org/10.1016/j.jhep.2019.08.008
Dahlan, A. K., Umrah, A. S., & Abeng, T. (2018). Kesehatan Lansia: Kajian Teori Gerontologi dan Pendekatan Asuhan pada Lansia. Malang: Intimedia.
Damalas, C., & Koutroubas, S. (2016). Farmers’ Exposure to Pesticides: Toxicity Types and Ways of Prevention. Toxics, 4(1), 1. https://doi.org/10.3390/toxics4010001
Freire, C., Koifman, R. J., & Koifman, S. (2015). Hematological and Hepatic Alterations in Brazilian Population Heavily Exposed to Organochlorine Pesticides. Journal of Toxicology and Environmental Health, Part A, 78(8), 534–548. https://doi.org/10.1080/15287394.2014.999396
Hassaan, M. A., & El Nemr, A. (2020). Pesticides pollution: Classifications, human health impact, extraction and treatment techniques. The Egyptian Journal of Aquatic Research, 46(3), 207–220. https://doi.org/10.1016/j.ejar.2020.08.007
Jamal, F., Haque, Q. S., Singh, S., & Arshad, M. (2015). The Influence of Pesticides on Hepatic and Renal Functions in Occupational Sprayers of Rural Malihabad, Lucknow (India). Toxicology: Open Access, 1(01). https://doi.org/10.4172/2476-2067.1000106
Koutros, S., Silverman, D. T., Alavanja, M. C., Andreotti, G., Lerro, C. C., Heltshe, S., Lynch, C. F., Sandler, D. P., Blair, A., & Beane Freeman, L. E. (2016). Occupational exposure to pesticides and bladder cancer risk. International Journal of Epidemiology, 45(3), 792–805. https://doi.org/10.1093/ije/dyv195
Lala, V., Zubair, M., & Minter, D. A. (2022). Liver Function Tests. StatPearls. Treasure Island (FL). Retrieved from https://pubmed.ncbi.nlm.nih.gov/29494096/
Lozano-Paniagua, D., Parrón, T., Alarcón, R., Requena, M., López-Guarnido, O., Lacasaña, M., & Hernández, A. F. (2021). Evaluation of conventional and non-conventional biomarkers of liver toxicity in greenhouse workers occupationally exposed to pesticides. Food and Chemical Toxicology, 151, 112127. https://doi.org/10.1016/j.fct.2021.112127
Luo, J.-C., Cheng, T.-J., Kuo, H.-W., & Chang, M. J. W. (2005). Abnormal liver function associated with occupational exposure to dimethylformamide and glutathione S -transferase polymorphisms. Biomarkers, 10(6), 464–474. https://doi.org/10.1080/13547500500333648
Malaguarnera, G. (2012). Toxic hepatitis in occupational exposure to solvents. World Journal of Gastroenterology, 18(22), 2756. https://doi.org/10.3748/wjg.v18.i22.2756
Manfo, F. P. T., Mboe, S. A., Nantia, E. A., Ngoula, F., Telefo, P. B., Moundipa, P. F., & Cho-Ngwa, F. (2020). Evaluation of the Effects of Agro Pesticides Use on Liver and Kidney Function in Farmers from Buea, Cameroon. Journal of Toxicology, 2020, 1–10. https://doi.org/10.1155/2020/2305764
Melaram, R. (2021). Environmental Risk Factors Implicated in Liver Disease: A Mini-Review. Frontiers in Public Health, 9, 683719. https://doi.org/10.3389/fpubh.2021.683719
Mrema, E. J., Ngowi, A. V., Kishinhi, S. S., & Mamuya, S. H. (2017). Pesticide Exposure and Health Problems Among Female Horticulture Workers in Tanzania. Environmental Health Insights, 11, 117863021771523. https://doi.org/10.1177/1178630217715237
Nieradko-Iwanicka, B., & Borzęcki, A. (2015). Effect of 28-Day Exposure to Fenpropathrin on the Activities of Serum Alanine Transaminase and Liver Antioxidant Enzymes in Mice. Bulletin of the Veterinary Institute in Pulawy, 59(1), 165–169. https://doi.org/10.1515/bvip-2015-0025
Rapisarda, V., Loreto, C., Malaguarnera, M., Ardiri, A., Proiti, M., Rigano, G., Frazzetto, E., Ruggeri, M. I., Malaguarnera, G., Bertino, N., Malaguarnera, M., Catania, V. E., Di Carlo, I., Toro, A., Bertino, E., Mangano, D., & Bertino, G. (2016). Hepatocellular carcinoma and the risk of occupational exposure. World Journal of Hepatology, 8(13), 573. https://doi.org/10.4254/wjh.v8.i13.573
Redlich, C. A. (1988). Liver Disease Associated with Occupational Exposure to the Solvent Dimethylformamide. Annals of Internal Medicine, 108(5), 680. https://doi.org/10.7326/0003-4819-108-5-680
Rizzati, V., Briand, O., Guillou, H., & Gamet-Payrastre, L. (2016). Effects of pesticide mixtures in human and animal models: An update of the recent literature. Chemico-Biological Interactions, 254, 231–246. https://doi.org/10.1016/j.cbi.2016.06.003
Sukmayanti, N. L. P. A., Artini, N. P. R., & Yanti, N. P. W. (2020). Analisis Kadar SGPT (Serum Glutamic Pyruvic Transaminase) Dan Kholinesterase Pada Petani Sayur Di Desa Riang Gede, Kecamatan Penebel, Kabupaten Tabanan. THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST, 3(2), 25. https://doi.org/10.30651/jmlt.v3i2.5841
Tostado, L., & Bollmohr, S. (2022). Facts and figures about toxic chemicals in agriculture 2022. Creative Commons, 1st edition. Retrieved from https://eu.boell.org/PesticideAtlas
Tsani, R. A., Setiani, O., & Dewanti, N. A. Y. (2017). Hubungan Riwayat pajanan pestisida dengan gangguan fungsi hati pada petani di desa sumberejo kecamatan ngablak kabupaten magelang. Jurnal Kesehatan Masyarakat, 5(3), 411-419. https://doi.org/10.14710/jkm.v5i3.17258
VoPham, T., Bertrand, K. A., Hart, J. E., Laden, F., Brooks, M. M., Yuan, J.-M., Talbott, E. O., Ruddell, D., Chang, C.-C. H., & Weissfeld, J. L. (2017). Pesticide exposure and liver cancer: A review. Cancer Causes & Control, 28(3), 177–190. https://doi.org/10.1007/s10552-017-0854-6
Yokoyama, Y., Ono, A., Yoshida, M., Matsumoto, K., & Saito, M. (2019). Toxicological significance of increased serum alkaline phosphatase activity in dog studies of pesticides: Analysis of toxicological data evaluated in Japan. Regulatory Toxicology and Pharmacology, 109, 104482. https://doi.org/10.1016/j.yrtph.2019.104482
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