Therapeutic Effects of Garlic (Allium Sativum) Compounds from Different Pretreatment Processes on Women's Reproductive Health: A Narrative Review
DOI:
https://doi.org/10.31965/infokes.Vol22.Iss3.1610Keywords:
Garlic, Reproductive Health, S-allyl cysteine, WomenAbstract
Women’s reproductive health disorders occur due to oxidative stress and can be treated with antioxidant intake. One of them is by utilizing the phytochemical content of garlic (Allium sativum). The semi-systematic review method helps authors to identify the pretreatment of garlic compound S-allyl cysteine (SAC) on women's reproductive health. The literature collection was adjusted to the study of the treatment of garlic compounds with search keywords used “Garlic”, “Reproductive health”, “S-allyl cysteine”, and “Women”. The sources used come from online publications from 2010 to 2024. The form of research in the literature review was carried out on test animals, test cells, and test treatments on humans. The selection of information in the reviewed article refers to the year of publication, test products, sample objects, research methods, results, and discussion. The interpretation of the results will be explained descriptively based on the review analysis. Ten study articles have a positive effect of garlic compounds on women's reproductive health. The pretreatment carried out was garlic extract, garlic powder, hexane extract of aged black garlic, dried garlic powder, and aged garlic (black) extract. This review shows that garlic has a main compound S-allyl cysteine (SAC). The bioactive components of garlic can stimulate antioxidant activity and increase the fertility of reproductive organs because it increases the metabolism of oocytes, hormonal regulation, and the maturation of the endometrium. The results of garlic pretreatment showed that aged garlic (black garlic) extract contained S-allyl cysteine (SAC) with more compounds, was more stable, soluble in water, and had minimal toxic content. It allows black garlic (SAC) to have prophylactic properties at the clinical level, so it is possible to develop research on black garlic's effects on women's reproductive health.
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References
Abood, W. N. (2017). Immunomodulatory and Natural Immunomodulators. J. Allergy Inflamm, 1(2), 1-4.
Ajiningrum PS, Amilah S, & W.P. (2020). Efektivitas Ekstrak Rimpang Pacing (Costus speciosus), Daun Srikaya (Annona squamosa L.) dan Ekstrak Kombinasinya terhadap Penurunan Jumlah Folikel Tersier dan Folikel De Graff pada Mencit Betina (Mus musculus). Journal of Pharmacy and Science. 5(1), 33–37. Doi: 10.53342/pharmasci.v5i1.164
Akbar, H., Qasim, M., Hidayani, W. R., Ariantini, N. S., Ramli., Gustirini, R., Simamora, J. P., Alang, H., handayani, F., & Paulus, A.Y. (2021). Teori Kesehatan Reproduksi. Aceh: Yayasan Penerbit Muhammad Zaini.
Amirsalari, S., Behboodi Moghadam, Z., Taghizadeh, Z., Jafar Abadi, M. N., Sabaghzadeh Irani, P., Goodarzi, S., & Ranjbar, H. (2021). The effect of garlic tablets on the endometriosis-related pains: a randomized placebo-controlled clinical trial. Evidence-Based Complementary and Alternative Medicine. 2021. 1-9. https://doi.org/10.1155/2021/5547058
Assayed, M. E., Khalaf, A. A., & Salem, H. A. (2010). Protective effects of garlic extract and vitamin C against in vivo cypermethrin-induced teratogenic effects in rat offspring. Food and Chemical Toxicology, 48(11), 3153–3158. https://doi.org/10.1016/j.fct.2010.08.011
Azhar, S. F., & Yuliawati, K. M. (2021). Pengaruh waktu aging dan metode ekstraksi terhadap aktivitas antioksidan black garlic yang dibandingkan dengan bawang putih (Allium sativum L.). Jurnal Riset Farmasi, 1(1). 16-23. https://doi.org/10.29313/jrf.v1i1.43
Balamurugan, N., Sundaram, S. M., Sivakumar, T., & Rajkumar, J. S. I. (2015). Effect of garlic (Allium sativum) supplementation on the growth performance of crossbred calves. Animal Production, 16(2), 78-87.
Bronowicka-Adamska, P., Bentke, A., Lasota, M., & Wróbel, M. (2020). Effect of S-allyl–l-cysteine on MCF-7 cell line 3-mercaptopyruvate sulfurtransferase/sulfane sulfur system, viability and apoptosis. International journal of molecular sciences, 21(3), 1090. 1-17. https://doi.org/10.3390/ijms21031090
Chang, T. C., & Jang, H. D. (2021). Optimization of aging time for improved antioxidant activity and bacteriostatic capacity of fresh and black garlic. Applied Sciences, 11(5), 2377. https://doi.org/10.3390/app11052377
Falahatian, S., Haddad, R., & Pakravan, N. (2022). Modulatory effects of R10 fraction of garlic (Allium sativum L.) on hormonal levels, T cell polarization, and fertility-related genes in mice model of polycystic ovarian syndrome. Journal of Ovarian Research, 15(4), 1-10. https://doi.org/10.1186/s13048-021-00926-6
Falahatian, S., Pakravan, N., & Haddad, R. (2024). The Effects of R10 Fraction of Garlic (Allium sativum L.) on Gonadotropins and Oocyte Maturation in a PCOS Mouse Model. Journal of Applied Biotechnology Reports, 11(1), 1245-1251. https://doi.org/10.30491/JABR.2023.392957.1625
Gamboa-León, M. R., Aranda-González, I., Mut-Martín, M., García-Miss, M. R., & Dumonteil, E. (2007). In vivo and In vitro Control of Leishmania mexicana due to Garlic-induced No Production. Scandinavian Journal of Immunology, 66(5), 508–514. https://doi.org/10.1111/j.1365-3083.2007.02000.x
Hagag, O.Y.A.-E.; Younis, F.E.-E.; Al-Eisa, R.A.; Fayad, E.; El-Shenawy, N.S. Effect of Feeding Pomegranate (Punica granatum) Peel and Garlic (Allium sativum) on Antioxidant Status and Reproductive Efficiency of Female Rabbits. Vet. Sci. 2023, 10, 179. https://doi.org/ 10.3390/vetsci10030179
Hajiuon, B. (2014). Effects of garlic (Allium sativum L.) hydroalcoholic extract on estrogen, progesterone and testosterone levels in rats exposed to cell phone radiation. Zahedan Journal of Research in Medical Sciences, 16(12), 20-25.
Jafari, F., Khalilzadeh, S., & Nejatbakhsh, F. (2023). Therapeutic effects of garlic (Allium sativum) on female reproductive system: A systematic review. Heliyon, 9(12). https://doi.org/doi.org/10.1016/j.heliyon.2023.e22555
Jafari, S., Farokhi, F., & Sadeghi, A. (2021). Comparative effects of garlic (Allium sativum) powder and atorvastatin in female reproductive system of hypercholesterolemic rats: A histological and biochemical evaluation. Journal of Shahrekord University of Medical Sciences, 23(3), 131-138. https://doi.org/10.34172/jsums.2021.22
Kasuga, S., Uda, N., Kyo, E., Ushijima, M., Morihara, N., & Itakura, Y. (2001). Pharmacologic activities of aged garlic extract in comparison with other garlic preparations. The Journal of nutrition, 131(3), 1080S-1084S. https://doi.org/10.1093/jn/131.3.1080S
Kim, K. H., Park, J. K., Choi, Y. W., Kim, Y. H., Lee, E. N., Lee, J. R., Kim, H. S., Baek, S. Y., Kim, B. S., Lee, K. S., & Yoon, S. (2013). Hexane extract of aged black garlic reduces cell proliferation and attenuates the expression of ICAM-1 and VCAM 1 in TNF-α-activated human endometrial stromal cells. International journal of molecular medicine, 32(1), 67-78. https://doi.org/10.3892/ijmm.2013.1362
Kimura, S. et al. (2016). A Critical Review of Its Production, Bioactivity, and Application. Journal of Food and Drug Analysis. 25(1). 62-70. https://doi.org/10.1016/j.jfda.2016.11.003.
Krumm, P., Giraldez, T., de la Rosa, D. A., Clauss, W. G., Fronius, M., & Althaus, M. (2012). Thiol-reactive compounds from garlic inhibit the epithelial sodium channel (ENaC). Bioorganic & Medicinal Chemistry, 20(13), 3979–3984. https://doi.org/10.1016/j.bmc.2012.05.021
Minami, A., Mikami, Y., Kano, T., Matsushita, H., Fujita, Y., Yoshimura, M., Abe, Y., Watanabe, H., Hara, M., Kurebayashi, Y., Takashi, T., Kanazawa, H., Wakatsuki, A., & Suzuki, T. (2020). Mitigation of memory impairment in ovariectomized rats using garlic powder treated with subcritical water. Biological and Pharmaceutical Bulletin, 43(3), 546-549. https://doi.org/10.1248/bpb.b19-00311
Prasonto, D., Riyanti, E., & Gartika, M. (2017). Uji aktivitas antioksidan ekstrak bawang putih (Allium sativum). ODONTO Dental Journal, 4(2). 122-128. vol 4 no 2.1.1 (core.ac.uk)
Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of business research, 104, 333-339. https://doi.org/10.1016/j.jbusres.2019.07.039
Suleria, H. A. R., Butt, M. S., Anjum, F. M., Saeed, F., Batool, R., & Nisar Ahmad, A. (2012). Aqueous garlic extract and its phytochemical profile; special reference to antioxidant status. International Journal of Food Sciences and Nutrition, 63(4), 431–439. https://doi.org/10.3109/09637486.2011.634786
Takemura, S., Ichikawa, H., Naito, Y., Takagi, T., Yoshikawa, T., & Minamiyama, Y. (2014). S-allyl cysteine ameliorates the quality of sperm and provides protection from age-related sperm dysfunction and oxidative stress in rats. Journal of clinical biochemistry and nutrition, 55(3), 155-161. https://doi.org/10.3164/jcbn.14-39
Toledano Medina, M. Á., Merinas-Amo, T., Fernández-Bedmar, Z., Font, R., del Río-Celestino, M., Pérez-Aparicio, J., Moreno-Ortega, A., Alonso-Moraga, Á., & Moreno-Rojas, R. (2019). Physicochemical characterization and biological activities of black and white garlic: In vivo and in vitro assays. Foods, 8(6), 1-18. https://doi.org/10.3390/foods8060220
Verma, T., Aggarwal, A., Dey, P., Chauhan, A. K., Rashid, S., Chen, K. T., & Sharma, R. (2023). Medicinal and therapeutic properties of garlic, garlic essential oil, and garlic-based snack food: An updated review. Frontiers in Nutrition, 10, 1-16. https://doi.org/10.3389/fnut.2023.1120377
Wang, Y., Wang, H. L., Xing, G. D., Qian, Y., Zhong, J. F., & Chen, K. L. (2021). S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs. Toxicology and Applied Pharmacology, 416. 1-10. https://doi.org/10.1016/j.taap.2021.115469
Waseem, N., Butt, S. A., & Hamid, S. (2015). Garlic Ameliorates Histological Changes In The Uterine Epithelium Of Lead Induced Mice: Garlic Ameliorates Effect in The Uterine Epithelium. Pakistan Armed Forces Medical Journal, 65(2), 202-205. Retrieved from: https://pafmj.org/PAFMJ/article/view/758
Xu, Y., Su, D., Zhu, L., Zhang, S., Ma, S., & Wu, K. S-allylcysteine suppresses ovarian cancer cell proliferation by DNA methylation through DNMT1. J Ovarian Res. 11(39). 1-8. https://doi.org/10.1186/s13048-018-0412-1
Yoga, W. K., & Komalasari, H. (2022). Potensi Alga Hijau (Caulerpa Racemosa) Sebagai Sumber Antioksidan Alami. Jurnal Teknologi dan Mutu Pangan, 1(1), 16-20. https://doi.org/10.30812/jtmp.v1i1.2172
Yuslianti, E. R. (2018). Pengantar radikal bebas dan antioksidan. Yogyakarta: Deepublish..
Zadhoush, R., Alavi-Naeini, A., Feizi, A., Naghshineh, E., & Ghazvini, M. R. (2023). The therapeutic impact of garlic (Allium Sativum) on oxidative stress markers among polycystic ovary syndrome patients: A randomized, double-blinded clinical trial. International Journal of Preventive Medicine, 14(1), 1-7. https://doi.org/10.4103/ijpvm.ijpvm_229_21
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