Papaya Juice Treatment Increases Body Weight and Decreases Urea Levels in Lead acetate-exposed Wistar Rats

Devi Etivia Purlinda; Nanik Aryani Putri; Widodo Widodo; Fitriani Kahar

doi:10.31965/infokes.Vol22.Iss1.1148

Authors

Devi Etivia Purlinda Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Semarang, Semarang, Central Java, Indonesia
Nanik Aryani Putri Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Semarang, Semarang, Central Java, Indonesia
Widodo Widodo Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Semarang, Semarang, Central Java, Indonesia
Fitriani Kahar Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Semarang, Semarang, Central Java, Indonesia

DOI:

https://doi.org/10.31965/infokes.Vol22.Iss1.1148

Keywords:

Papaya Juice, Body Weight, Ureum Levels, Lead Acetate

Abstract

Lead (Pb) exposure poses significant health risks due to its non-degradable nature and profound toxicity, causes oxidative stress and organ damage, particularly targeting the kidneys. Urea nitrogen levels rise as a result of decreased renal filtration rate and urea excretion. This study investigates the potential of papaya juice, rich in flavonoids, vitamins C, E, and beta-carotene, as a protective agent against Pb-induced nephrotoxicity. A Completely Randomized Design experiment was conducted, involving six treatment groups of Wistar rats. Papaya juice was administered at doses of 3.6, 7.2, and 14.4 g/200g body weight (BW) to Groups P1, P2, and P3, respectively, prior to exposure to 50 mg/kg BW of lead acetate. Group PC received vitamin E (400 IU/kg BW) and lead acetate, while Group NC was exposed to lead acetate alone. Group NT served as the control. Following a 28-day treatment period, the P3 group exhibited the most significant improvements, with a notable increase in body weight (22.50 grams) and a substantial decrease in urea nitrogen levels (18.24 mg/dl). These findings underscore the efficacy of papaya juice treatment in mitigating Pb-induced nephrotoxicity, suggesting a potential therapeutic regimen for alleviating lead toxicity in exposed populations. Eventually, the optimal dosing for papaya juice treatment, either at 14.4 g per 200 g body weight for rats or consumption of one medium-sized papaya for humans, yields compelling benefits. This regimen demonstrates significant efficacy in increasing body weight and lowering serum urea levels in rats subjected to Pb acetate exposure.

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