Immunological Profile of Patients with Controlled and Uncontrolled Type 2 Diabetes Melitus in Mataram City, West Nusa Tenggara
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The prevalence of DM disease in West Nusa Tenggara Province is not much different from that in Indonesia. DM cases in NTB are included in the ten most non-communicable illnesses suffered by the community and the incidence continues to increase from year to year. An increase in the levels of pro-inflammatory cytokines in the body is one of the causes of insulin resistance in cells which can further develop into type 2 diabetes. This study involved diabetic patients at the Mataram Community Health Center, who were assigned into 2 groups, namely the controlled diabetes group and the uncontrolled diabetes group and involved a standard group which was a group consisted of healthy people. Each group was examined for Fasting Blood Glucose (FBG) and HbA1c levels. The results of the examination in the standard group, controlled diabetes group and uncontrolled diabetes group obtained the FBG levels of 89.22 mg/dl, 110.0 mg/dl, and 245.80 mg/dl, respectively. Furthermore, the results of the HbA1c test in the standard group, controlled diabetes group and uncontrolled diabetes group were 5.44%, 6.03%, and 10.49%, respectively. The results of the examination of IL-6 levels in the standard group, controlled diabetes group and uncontrolled diabetes were 329.36 pg/ml, 331.52 pg/ml, and 320.33 pg/ml, respectively. The results of the IL-10 test in the standard group, controlled diabetes group and uncontrolled diabetes were 71.80 pg/ml, 116.60 pg/ml, and 128.10 pg/ml, respectively. Based on the results of the study, there was no significant difference in the levels of interleukin 6 and interleukin 10 between respondents with diabetes mellitus and healthy respondents (p>0.05). It can be concluded that there were no differences in interleukin 6 and 10 levels between healthy people with patients with controlled and uncontrolled diabetes.
Ahmed, M. H., Ghatge, M. S., & Safo, M. K. (2020). Hemoglobin: structure, function and allostery. Vertebrate and invertebrate respiratory proteins, lipoproteins and other body fluid proteins, 94, 345-382. https://doi.org/10.1007/978-3-030-41769-7_14
Akash, M. S. H., Rehman, K., & Liaqat, A. (2018). Tumor necrosis factor‐alpha: role in development of insulin resistance and pathogenesis of type 2 diabetes mellitus. Journal of cellular biochemistry, 119(1), 105-110. https://doi.org/10.1002/jcb.26174
Amir, S. M., Wungouw, H., & Pangemanan, D. (2015). Kadar glukosa darah sewaktu pada pasien diabetes melitus tipe 2 di Puskesmas Bahu kota Manado. e-Biomedik, 3(1), 32-40. Retrieved from https://ejournal.unsrat.ac.id/index.php/ebiomedik/article/view/6505
Annisa, B. S., Puspitasari, C. E., & Aini, S. R. J. S. J. P. (2021). Profil penggunaan obat antidiabetes pada pasien diabetes mellitus tipe 2 di instalasi rawat jalan RSUD Provinsi NTB tahun 2018. 2(1), 37-41. https://doi.org/10.29303/sjp.v2i1.74
Asril, N. M., Tabuchi, K., Tsunematsu, M., Kobayashi, T., Kakehashi, M. J. C. M. I. E., & Diabetes. (2020). Predicting healthy lifestyle behaviours among patients with type 2 diabetes in rural bali, Indonesia. 13, 1179551420915856. https://doi.org/10.1177/1179551420915856
Babu, S., Krishnan, M., Rajagopal, P., Periyasamy, V., Veeraraghavan, V., Govindan, R., & Jayaraman, S. J. E. J. o. P. (2020). Beta-sitosterol attenuates insulin resistance in adipose tissue via IRS-1/Akt mediated insulin signaling in high fat diet and sucrose induced type-2 diabetic rats. 873, 173004. https://doi.org/10.1016/j.ejphar.2020.173004
Bolte, L. A., Vila, A. V., Imhann, F., Collij, V., Gacesa, R., Peters, V., . . . Fu, J. (2021). Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome. Gut, 70(7), 1287-1298. http://dx.doi.org/10.1136/gutjnl-2020-322670
Castro, A., Macedo-de La Concha, L., & Pantoja-Meléndez, C. (2017). Low-grade inflammation and its relation to obesity and chronic degenerative diseases. Revista Médica del Hospital General de México, 80(2), 101-105. https://doi.org/10.1016/j.hgmx.2016.06.011
Dağ, A., Fırat, E., Arıkan, Ş., Kadiroğlu, A., & Kaplan, A. (2009). The effect of periodontal therapy on serum TNF‐α and HbA1c levels in type 2 diabetic patients. Australian dental journal, 54(1), 17-22. https://doi.org/10.1111/j.1834-7819.2008.01083.x
Dasu, M. R., Devaraj, S., Park, S., & Jialal, I. (2010). Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects. Diabetes care, 33(4), 861-868. https://doi.org/10.2337/dc09-1799
Den Hartogh, D. J., Vlavcheski, F., Giacca, A., & Tsiani, E. J. I. J. o. M. S. (2020). Attenuation of free fatty acid (FFA)-induced skeletal muscle cell insulin resistance by resveratrol is linked to activation of AMPK and inhibition of mTOR and p70 S6K. 21(14), 4900. https://doi.org/10.3390/ijms21144900
Ellulu, M. S., Patimah, I., Khaza’ai, H., Rahmat, A., & Abed, Y. (2017). Obesity and inflammation: the linking mechanism and the complications. Archives of medical science, 13(4), 851-863. https://doi.org/10.5114/aoms.2016.58928
Forero, R., Nahidi, S., De Costa, J., Mohsin, M., Fitzgerald, G., Gibson, N., . . . Aboagye-Sarfo, P. J. B. h. s. r. (2018). Application of four-dimension criteria to assess rigour of qualitative research in emergency medicine. 18(120), 1-11. https://doi.org/10.1186/s12913-018-2915-2
Giri, A. B., Shinde, V. T., Lengare, P. R., Shinde, R. D. J. G. B., & Sciences, P. (2020). Lifestyle modifications: A key to manage diabetes. 13(3), 141-148. https://doi.org/10.30574/gscbps.2020.13.3.0405
Grosick, R., Alvarado-Vazquez, P. A., Messersmith, A. R., & Romero-Sandoval, E. A. (2018). High glucose induces a priming effect in macrophages and exacerbates the production of pro-inflammatory cytokines after a challenge. Journal of pain research, 11, 1769. https://doi:10.2147/JPR.S164493
Guo, X., Cheng, L., Yang, S., & Che, H. (2020). Pro-inflammatory immunological effects of adipose tissue and risk of food allergy in obesity: Focus on immunological mechanisms. Allergologia et immunopathologia, 48(3), 306-312. https://doi.org/10.1016/j.aller.2019.06.004
Gupta, S., Jain, U., & Chauhan, N. (2017). Laboratory diagnosis of HbA1c: a review. J Nanomed Res, 5(4), 00120. http://doi.org/10.15406/jnmr.2017.05.00120
Hong, Y.-p., Yu, J., Su, Y.-r., Mei, F.-c., Li, M., Zhao, K.-l., . . . Wang, W.-x. (2020). High-fat diet aggravates acute pancreatitis via TLR4-mediated necroptosis and inflammation in rats. Oxidative Medicine and Cellular Longevity, 2020(8172714). https://doi.org/10.1155/2020/8172714
Khan, M. A. B., Hashim, M. J., King, J. K., Govender, R. D., Mustafa, H., Al Kaabi, J. J. J. o. e., & health, g. (2020). Epidemiology of type 2 diabetes–global burden of disease and forecasted trends. 10(1), 107. https://doi.org/10.2991/jegh.k.191028.001
Kida, T., Oku, H., Osuka, S., Horie, T., & Ikeda, T. (2021). Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, rapamycin. Scientific reports, 11(1885). https://doi.org/10.1038/s41598-021-81482-3
Matsubara, T., Mita, A., Minami, K., Hosooka, T., Kitazawa, S., Takahashi, K., . . . Matsuo, E.-i. (2012). PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue. Cell metabolism, 15(1), 38-50. https://doi.org/10.1016/j.cmet.2011.12.002
Muralidharan, M., Bhat, V., & Mandal, A. K. (2020). Structural analysis of glycated human hemoglobin using native mass spectrometry. The FEBS Journal, 287(6), 1247-1254. https://doi.org/10.1111/febs.15085
Paputungan, S. R., & Sanusi, H. (2014). Peranan Pemeriksaan Hemoglobin A1c pada Pengelolaan Diabetes Melitus. Cermin Dunia Kedokteran, 41(9), 650-655. http://dx.doi.org/10.55175/cdk.v41i9.1103
Poznyak, A., Grechko, A. V., Poggio, P., Myasoedova, V. A., Alfieri, V., & Orekhov, A. N. J. I. j. o. m. s. (2020). The diabetes mellitus–atherosclerosis connection: The role of lipid and glucose metabolism and chronic inflammation. 21(5), 1835. https://doi.org/10.3390/ijms21051835
Pradono, J., Delima, D., Kusumawardani, N., Dany, F., & Kristanto, Y. J. G. J. o. H. S. (2021). Contribution of Metabolic Syndrome in Controlling Diabetes Mellitus According to Gender in Indonesia (RISKESDAS 2018). 13(1), 1-46. https://doi.org/10.5539/gjhs.v13n1p46
Primayanti, I., Danianto, A., Jumsa, R., Geriputri, N., & Andari, M. Y. J. J. K. (2022). Gambaran Epidemiologi Faktor Risiko Preeklamsia Pada Ibu Hamil. 11(1), 785-788. https://doi.org/10.29303/jku.v11i1.624
Sabat, R., Grütz, G., Warszawska, K., Kirsch, S., Witte, E., Wolk, K., & Geginat, J. (2010). Biology of interleukin-10. Cytokine & growth factor reviews, 21(5), 331-344. http://dx.doi.org/10.1016/j.cytogfr.2010.09.002
Sacerdote, A., Dave, P., Lokshin, V., & Bahtiyar, G. J. C. d. r. (2019). Type 2 diabetes mellitus, insulin resistance, and vitamin D. 19(10), 1-12. https://doi.org/10.1007/s11892-019-1201-y
Saraiva, M., & O'garra, A. (2010). The regulation of IL-10 production by immune cells. Nature reviews immunology, 10, 170-181. http://dx.doi.org/10.1038/nri2711
Sheng, Z., Cao, J.-Y., Pang, Y.-C., Xu, H.-C., Chen, J.-W., Yuan, J.-H., . . . Dong, J. J. F. i. e. (2019). Effects of lifestyle modification and anti-diabetic medicine on prediabetes progress: A systematic review and meta-analysis. 10, 455. https://doi.org/10.3389/fendo.2019.00455
Sherwani, S. I., Khan, H. A., Ekhzaimy, A., Masood, A., & Sakharkar, M. K. (2016). Significance of HbA1c test in diagnosis and prognosis of diabetic patients. Biomarker insights, 11, BMI. S38440. https://doi.org/10.4137/BMI.S38440
Silverman, R. A., Pahk, R., Carbone, M., Wells, E., Mitzner, R., Burris, K., . . . Katzeff, H. (2006). The relationship of plasma glucose and HbA1c Levels among emergency department patients with no prior history of diabetes mellitus. Academic emergency medicine, 13(7), 722-726. https://doi.org/10.1197/j.aem.2006.02.012
Trayhurn, P., & Wood, I. (2005). Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochemical Society Transactions, 33(5), 1078-1081. https://doi.org/10.1042/BST0331078
Utomo, M. R., Wungouw, H., & Marunduh, S. (2015). Kadar Hba1C Pada Pasien Diabetes Melitus Tipe 2 Di Puskesmas Bahu Kecamatan Malalayang Kota Manado. eBiomedik, 3(1). Retrieved from https://ejournal.unsrat.ac.id/index.php/ebiomedik/article/view/6620
Villarroya, F., Cereijo, R., Gavaldà‐Navarro, A., Villarroya, J., & Giralt, M. (2018). Inflammation of brown/beige adipose tissues in obesity and metabolic disease. Journal of internal medicine, 284(5), 492-504. https://doi.org/10.1111/joim.12803
Volpe, C. M. O., Villar-Delfino, P. H., Dos Anjos, P. M. F., Nogueira-Machado, J. A. J. C. d., & disease. (2018). Cellular death, reactive oxygen species (ROS) and diabetic complications. 9(2), 1-9. https://doi.org/10.1038/s41419-017-0135-z
Wang, T., & He, C. (2018). Pro-inflammatory cytokines: The link between obesity and osteoarthritis. Cytokine & growth factor reviews, 44, 38-50. https://doi.org/10.1016/j.cytogfr.2018.10.002
Wang, Z., Wang, Z., Huang, W., Suo, J., Chen, X., Ding, K., . . . Zhang, H. (2020). Antioxidant and anti-inflammatory activities of an anti-diabetic polysaccharide extracted from Gynostemma pentaphyllum herb. International journal of biological macromolecules, 145, 484-491. https://doi.org/10.1016/j.ijbiomac.2019.12.213
Xu, L.-N., Yin, L.-H., Jin, Y., Qi, Y., Han, X., Xu, Y.-W., . . . Peng, J.-Y. (2020). Effect and possible mechanisms of dioscin on ameliorating metabolic glycolipid metabolic disorder in type-2-diabetes. Phytomedicine, 67, 153139. https://doi.org/10.1016/j.phymed.2019.153139
Yeo, D., Hwang, S. J., Kim, W. J., Youn, H.-J., Lee, H.-J. J. B., & Pharmacotherapy. (2018). The aqueous extract from Artemisia capillaris inhibits acute gastric mucosal injury by inhibition of ROS and NF-kB. 99, 681-687. https://doi.org/10.1016/j.biopha.2018.01.118
Yezli, S., Mushi, A., Almuzaini, Y., Balkhi, B., Yassin, Y., Khan, A. J. I. J. o. E. R., & Health, P. (2021). Prevalence of diabetes and hypertension among Hajj pilgrims: a systematic review. 18(3), 1155. https://doi.org/10.3390/ijerph18031155
Yuan, N., Zhang, H.-f., Wei, Q., Wang, P., Guo, W.-y. J. E., Endocrinology, C., & Diabetes. (2018). Expression of CD4+ CD25+ Foxp3+ regulatory T cells, interleukin 10 and transforming growth factor β in newly diagnosed type 2 diabetic patients. 126(02), 96-101. https://doi.org/10.1055/s-0043-113454
Zamora, M., & Villena, J. A. J. I. j. o. m. s. (2019). Contribution of impaired insulin signaling to the pathogenesis of diabetic cardiomyopathy. 20(11), 2833. https://doi.org/10.3390/ijms20112833
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