Dose-Dependent Effect of Ethanol Extract of Red Ginger (Zingiber officinale var. rubrum) on Total Cholesterol Levels in Hypercholesterolemic Mice: An Experimental Study
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Cholesterol is an essential lipid in the body; however, excessive levels may lead to hypercholesterolemia and increase the risk of coronary heart disease. Natural alternatives such as red ginger extract (Zingiber officinale var. rubrum) have potential due to their antioxidant and anti-inflammatory properties. This study aimed to evaluate the effect and determine the optimal dose of red ginger extract in reducing total cholesterol levels. A laboratory experimental study with a pre-test and post-test control group design was conducted using 30 male mice (Mus musculus), which were randomly divided into five groups (three treatment groups and two control groups). The treatment groups received different doses of red ginger ethanol extract. The results showed that administration of red ginger extract reduced total cholesterol levels in mice, with mean total cholesterol level decreased from 163.57 mg/dL to 131.87 mg/dL. Statistical analysis indicated a significant reduction in cholesterol levels, and differences were observed among treatment groups. The highest dose (18 mg/kg body weight) demonstrated the most optimal effect. In conclusion, red ginger ethanol extract effectively reduces total cholesterol levels in mice, with higher doses showing greater efficacy.
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