Aloe Vera: Potential to Reduce Fasting Blood Sugar Levels in Prediabetes
DOI:
https://doi.org/10.31965/infokes.Vol21.Iss3.1361Keywords:
Prediabetes, Fasting Blood Sugar Levels, Aloe Vera JuiceAbstract
Prediabetes is a continuous spectrum of developmental stages before a person is diagnosed with diabetes mellitus. Considering the long-term effects of pharmacological treatment, other natural-based methods are needed. The purpose of this study was to analyze the effect of Aloe Vera Juice on the reduction of fasting blood glucose levels in patients with prediabetes in Pontianak City. A pre and post-test design study was conducted between March and July 2021 at Alianyang Public Health Center. A total of 12 subjects were identified as prediabetic at the beginning of the study through screening involved in this study. The included subjects were asked to consume 175 ml of Aloe Vera Juice for 15 consecutive days and measured their fasting blood glucose (FBG) levels on the 16th day. A paired t-test was performed to determine the difference in FBG levels before and after the treatment. Present findings revealed that the mean FBG level before intervention was 107.4 mg / dL and 92.1 mg/dL after the intervention. A statistically different FBG reduction significance was found between groups (p<0.001). Consuming Aloe vera juice regularly for 15 days has proven to lower FBG levels among prediabetics. Future studies with better adherence monitor and larger sample sizes might have resulted in better determination of the intervention's effect.
Downloads
References
Alhassan, Y., Kwakye, A. O., Dwomoh, A. K., Baah-Nyarkoh, E., Ganu, V. J., Appiah, B., & Kretchy, I. A. (2022). Determinants of blood pressure and blood glucose control in patients with co-morbid hypertension and type 2 diabetes mellitus in Ghana: A hospital-based cross-sectional study. PLOS Global Public Health, 2(12), e0001342. https://doi.org/10.1371/journal.pgph.0001342
Alinejad-Mofrad, S., Foadoddini, M., Saadatjoo, S. A., & Shayesteh, M. (2015). Improvement of glucose and lipid profile status with Aloe vera in pre-diabetic subjects: A randomized controlled-trial. Journal of Diabetes and Metabolic Disorders, 14(1), 1–7. https://doi.org/10.1186/s40200-015-0137-2
American Diabetes Association. (2018). Factors affecting blood sugar. American Diabetes Association Clinical Diabetes, 36(2), 202. https://doi.org/10.2337/cd18-0012
Astuti, A. (2019). Usia, Obesitas dan Aktifitas Fisik Beresiko Terhadap Prediabetes. Jurnal Endurance, 4(2), 319. https://doi.org/10.22216/jen.v4i2.3757
Babu, S. N., Govindarajan, S., Vijayalakshmi, M. A., & Noor, A. (2021). Role of zonulin and GLP-1/DPP-IV in alleviation of diabetes mellitus by peptide/polypeptide fraction of Aloe vera in streptozotocin-induced diabetic wistar rats. Journal of Ethnopharmacology, 272, 113949. https://doi.org/10.1016/j.jep.2021.113949
Bansal, N. (2015). Prediabetes diagnosis and treatment: A review. World Journal of Diabetes, 6(2), 296. https://doi.org/10.4239/wjd.v6.i2.296
Budiastutik, I., Subagio, H. W., Kartasurya, M. I., Widjanarko, B., Kartini, A., Soegiyanto, & Suhartono, S. (2022). The effect of Aloe vera on fasting blood glucose levels in pre-diabetes and type 2 diabetes mellitus: A systematic review and meta-analysis. Journal of Pharmacy and Pharmacognosy Research, 10(4), 737–747. https://doi.org/10.56499/jppres22.1378_10.4.737
CDC. (2020). National Diabetes Statistics Report 2020. Estimates of diabetes and its burden in the United States. CDC
CDC. (2023). Diabetes Tests. U.S. Department of Health & Human Services. CDC. https://www.cdc.gov/diabetes/basics/getting-tested.html#:~:text=Fasting
Chaudhary, V., Bishnoi, S., & Argade, A. (2019). Development and characterization of aloe vera juice incorporated burfi. The Pharma Innovation Journal, 8(5), 407-411. https://doi.org/10.13140/RG.2.2.32307.48162
Choudhary, M., Kochhar, A., & Sangha, J. (2014). Hypoglycemic and hypolipidemic effect of Aloe vera L. in non-insulin dependent diabetics. Journal of Food Science and Technology, 51(1), 90–96. https://doi.org/10.1007/s13197-011-0459-0
Ciarambino, T., Crispino, P., Leto, G., Mastrolorenzo, E., Para, O., & Giordano, M. (2022). Influence of gender in diabetes mellitus and its complication. International Journal of Molecular Sciences, 23(16), 8850. https://doi.org/10.3390/ijms23168850
Deora, N., & Venkatraman, K. (2022). Aloe vera in diabetic dyslipidemia: Improving blood glucose and lipoprotein levels in pre-clinical and clinical studies. Journal of Ayurveda and Integrative Medicine, 13(4), 100675. https://doi.org/10.1016/j.jaim.2022.100675
Dick, W. R., Fletcher, E. A., & Shah, S. A. (2016). Reduction of fasting blood glucose and hemoglobin A1c using oral aloe vera: A meta-analysis. The Journal of Alternative and Complementary Medicine, 22(6), 450-457. https://doi.org/10.1089/acm.2015.0122
Hamman, J. H. (2008). Composition and applications of Aloe vera leaf gel. Molecules, 13(8), 1599-1616. https://doi.org/10.3390/molecules13081599
Istiana, M. (2019). Pengaruh Jus Lidah Buaya Terhadap Perubahan Kadar Gula Darah Pada Penderita Diabetes Mellitus DI Poli Penyakit Dalam Rumah Sakit Emma Kota Mojokerto. Journal of Chemical Information and Modeling, 53(9), 1689–1699.
Kabosu, R. A. S., Adu, A. A., & Hinga, I. A. T. (2019). Faktor Risiko Kejadian Diabetes Melitus Tipe Dua di RS Bhayangkara Kota Kupang. Timorese Journal of Public Health, 1(1), 11-20.
Kementerian Kesehatan Republik Indonesia. (2018). Hasil Riset Kesehatan Dasar Indonesia Tahun 2018. Kementerian Kesehatan Republik Indonesia.
Khalid, S. A., Samia, A. B., & Muneera, A. A. (2018). Associated Risk Factors in Pre-diabetes and Type 2 Diabetes in Saudi Community. Archives of Diabetes & Obesity, 1(2). https://doi.org/10.32474/ado.2018.01.000108
Kirkman, M. S., Briscoe, V. J., Clark, N., Florez, H., Haas, L. B., Halter, J. B., ... & Swift, C. S. (2012). Diabetes in older adults. Diabetes care, 35(12), 2650.–2664. https://doi.org/10.2337/dc12-1801
Kurniawaty, E., & Yanita, B. (2016). Faktor-faktor yang berhubungan dengan kejadian Diabetes Melitus tipe II. Jurnal Majority, 5(2), 27-31. Retrieved from https://juke.kedokteran.unila.ac.id/index.php/majority/article/view/1073
Kusnanto, K., Sriyono, S., & Astuti, D. E. P. (2008). Aloe Vera Juice Decrease the Amount of Blood Glucose Level in Patient with Diabetic Type II. Jurnal Ners, 3(1), 14-20. https://doi.org/10.20473/jn.v3i1.4974
Lee, G., Kim, S. M., Choi, S., Kim, K., Jeong, S. M., Son, J. S., ... & Park, S. M. (2018). The effect of change in fasting glucose on the risk of myocardial infarction, stroke, and all-cause mortality: a nationwide cohort study. Cardiovascular diabetology, 17, 1-10. https://doi.org/10.1186/s12933-018-0694-z
Liberty, I. A. (2016). Hubungan obesitas dengan kejadian prediabetes pada wanita usia produktif. Jurnal Kedokteran dan Kesehatan: Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya, 3(2), 108-113. Retrieved from https://ejournal.unsri.ac.id/index.php/jkk/article/view/5161
Malinti, E., & Jael, S. A. (2019). Aloe Vera Linn Gel Dan Gula Darah Puasa Pada Klien Prediabetes. Jurnal Skolastik Keperawatan, 5(1), 39–47. https://doi.org/10.35974/jsk.v5i1.773
McMillan, J. M., Mele, B. S., Hogan, D. B., & Leung, A. A. (2018). Impact of pharmacological treatment of diabetes mellitus on dementia risk: systematic review and meta-analysis. BMJ Open Diabetes Research and Care, 6(1), e000563. https://doi.org/10.1136/bmjdrc-2018-000563
Minjares-Fuentes, R., & Femenia, A. (2019). Chapter 3.4 - Aloe vera. In Nonvitamin and Nonmineral Nutritional Supplements, pp. 145–152. Academic Press. https://doi.org/10.1016/B978-0-12-812491-8.00020-5
PERKENI. (2015). KONSENSUS "Pengelolaan Dan Pencegahan Diabetes Mellitus Tipe 2 Di Indonesia. PERKENI.
PERKENI. (2019). Pengendalian dan Pencegahan Diabetes Mellitus tipe 2 pada orang Dewasa di Indonesia. PERKENI.
Pertiwi, P. S., & Rahayuningsih, H. M. (2012). Pengaruh Pemberian Jus Lidah Buaya Terhadap Kadar Glukosa Darah Puasa Pada Wanita Prediabetes. Journal of Nutrition College, 1(1), 107-114. https://doi.org/10.14710/jnc.v1i1.408
Rahoui, W., Merzouk, H., El Haci, I. A., Bettioui, R., Azzi, R., & Benali, M. (2018). Beneficial effects of Aloe vera gel on lipid profile, lipase activities and oxidant/antioxidant status in obese rats. Journal of functional foods, 48, 525-532. https://doi.org/10.1016/j.jff.2018.07.050
Sari, D. M. (2010). Pemanfaatan Lidah Buaya (Aloe vera) Terhadap Penurunan Kadar Gula Darah pada Penderita Diabetes Mellitus Tipe II di Kecamatan Rantau Selatan Kabupaten Labuhan Batu. Skripsi. Fakultas Keperawatan, Universiitas Sumatera Utara.
Soni, Y., Mochi, R., & Gahlot, G. (2014). Effect of aloe vera juice on diabetic and diabetic retinopathy subjects. Indian Journal of Life Sciences, 4(1), 41-46. Retrieved from https://go.gale.com/ps/i.do?id=GALE%7CA417738131&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=22771743&p=HRCA&sw=w&userGroupName=anon%7E733d7430&aty=open-web-entry
Surya, N., Magna, A., & Nuhriawangsa, P. (2020). The Effect of Aloe vera Juice Before Meals on Fasting Blood Sugar (FBS) Level of T2DM Patients. Indian Journal of Public Health Research & Development, 11(10), 324-330. https://doi.org/10.37506/ijphrd.v11i10.11170
Taylor, S. I., Yazdi, Z. S., & Beitelshees, A. L. (2021). Pharmacological treatment of hyperglycemia in type 2 diabetes. Journal of Clinical Investigation, 131(2). https://doi.org/10.1172/JCI142243
Trisnawati, S. K., & Setyorogo, S. (2013). Faktor risiko Kejadian diabetes melitus tipe II di puskesmas kecamatan cengkareng Jakarta Barat Tahun 2012. Jurnal ilmiah kesehatan, 5(1), 6-11.
Tziomalos, K., Athyros, V. G., Karagiannis, A., & Mikhailidis, D. P. (2011). Dyslipidemia induced by drugs used for the prevention and treatment of vascular diseases. The open cardiovascular medicine journal, 5, 85-89. http://doi.org/10.2174/1874192401105010085
WHO. (2023). Diabetes. WHO. Retrieved from https://www.who.int/health-topics/diabetes#tab=tab_1
Zhang, Y., Liu, W., Liu, D., Zhao, T., & Tian, H. (2016). Efficacy of Aloe vera supplementation on prediabetes and early non-treated diabetic patients: A systematic review and meta-analysis of randomized controlled trials. Nutrients, 8(7), 388. https://doi.org/10.3390/nu8070388
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 JURNAL INFO KESEHATAN
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Copyright notice
Ownership of copyright
The copyright in this website and the material on this website (including without limitation the text, computer code, artwork, photographs, images, music, audio material, video material and audio-visual material on this website) is owned by JURNAL INFO KESEHATAN and its licensors.
Copyright license
JURNAL INFO KESEHATAN grants to you a worldwide non-exclusive royalty-free revocable license to:
- view this website and the material on this website on a computer or mobile device via a web browser;
- copy and store this website and the material on this website in your web browser cache memory; and
- print pages from this website for your use.
- All articles published by JURNAL INFO KESEHATAN are licensed under the Creative Commons Attribution 4.0 International License. This permits anyone to copy, redistribute, remix, transmit and adapt the work provided the original work and source is appropriately cited.
JURNAL INFO KESEHATAN does not grant you any other rights in relation to this website or the material on this website. In other words, all other rights are reserved.
For the avoidance of doubt, you must not adapt, edit, change, transform, publish, republish, distribute, redistribute, broadcast, rebroadcast or show or play in public this website or the material on this website (in any form or media) without appropriately and conspicuously citing the original work and source or JURNAL INFO KESEHATAN prior written permission.
Permissions
You may request permission to use the copyright materials on this website by writing to jurnalinfokesehatan@gmail.com.
Enforcement of copyright
JURNAL INFO KESEHATAN takes the protection of its copyright very seriously.
If JURNAL INFO KESEHATAN discovers that you have used its copyright materials in contravention of the license above, JURNAL INFO KESEHATAN may bring legal proceedings against you seeking monetary damages and an injunction to stop you using those materials. You could also be ordered to pay legal costs.
If you become aware of any use of JURNAL INFO KESEHATAN copyright materials that contravenes or may contravene the license above, please report this by email to jurnalinfokesehatan@gmail.com
Infringing material
If you become aware of any material on the website that you believe infringes your or any other person's copyright, please report this by email to jurnalinfokesehatan@gmail.com.
